Scientific publications: Effects of nebulized antithrombin and heparin on inflammatory alterations

Scientific publications: Effects of nebulized antithrombin and heparin on inflammatory alterations 1024 512 William Cebrian

Last November, 2019, Dr. and Drs. Camprubí, Tantinyà, Guillamat, Bringué, Puig, Gómez, Blanch and Artigas, of the Parc Taulí Research and Innovation Institute (I3PT) of Sabadell, published a scientific article who was collecting his research on acute respiratory distress syndrome.

Next we talk to Dr. Marta Camprubí, who will tell us what the study has been and what the future prospects it hints at.

The background of this study is the treatment of acute respiratory distress syndrome. What is the worst affected segment of the population?

(Marta Camprubí). The incidence of this syndrome is difficult to predict due to demographic, cultural, genetic, economic and health system differences. In Europe, the incidence is 17 cases per 9 inhabitants per year, and in Spain it is 100.000 cases per 7 inhabitants per year. Although it may occur in patients of all ages, it is linked to elderly patients with a variability in clinical disorders. The most common causes of acute respiratory distress syndrome are pneumonia (2-100.000%), sepsis (35%), aspiration of gastric contents (50%), or trauma (30%).

For practical purposes: What did this study consist of?

(MC) The study involved determining whether direct administration of anticoagulants to the lung by their nebulization produces beneficial effects by reducing the excessive coagulation and inflammation that occurs in the syndrome without systemic hemorrhage.

What have been the results?

(MC) The Results show that both antithrombin and heparin reduce lung injury by decreasing coagulation and inflammation without altering systemic coagulation or hemorrhage.

Knowing the results, what would be the next step?

(MC) The the next step would be to determine if the effects of anticoagulants are sustained over time and if more doses can be enhanced. We also want to determine what mechanisms act by observing their effects specifically on different cell types such as alveolar macrophages or epithelial alveolar cells.

(at this point Dr. Artigas adds):

(AA) Once the additional missing studies regarding the duration of treatment and its effects on different cellular elements have been completed, a clinical study should be considered.

William Cebrian
William Cebrian

Graduate in Information and Documentation (UB) and Master in Management and Management of Libraries and Information Services (UB). At I3PT I am the Library Manager and I am in charge of collecting and disseminating its scientific production. I love new technologies, data management and open science.

All stories by: Guillem Cebrian

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