Inflammation, Immunology and Metabolism

  • About the area
  • Groups

This area of ​​research is complex and includes 13 lines that aim to study the pathophysiology or evolution of different diseases or procedures, in which inflammation, immunology and / or metabolic diseases are involved.

The relevance of this area lies in the diversity of disciplines involved, the transversality of most projects and the interaction and collaboration between the different lines.

Area coordination
Assumpt Caixàs Pedragós

acaixas@tauli.cat

Group A4G1 - Prader Willi syndrome and obesity

Accreditation level: Group in the consolidation phase

The group is made up of clinical researchers related to obesity and nutrition (endocrinologists, surgeons, nutritionists, neuropsychologists, psychiatrists), but also includes external collaborators exclusively dedicated to research (neuroradiologists, neuropsychologists specializing in data management). neuroimaging, etc.).

The research performed by the group is translational, from laboratory to follow-up for obese patients with and without Prader-Willi Syndrome (SPW). It aims to study different aspects of obesity that may be influenced by bariatric surgery (psychopathology, inflammation status, gut microbiome, etc.). The SPW aims to study the mechanisms of appetite and satiety, either at the peripheral level (gastrointestinal peptides) or at the central level (brain connectivity in areas for intake motivation or alternative areas). We also study the effect of growth hormone on adults with SPW on central hypotonia by functional MRI.

Areas of research

  • Morbid obesity. Effects of bariatric surgery on inflammation, metabolomics and microbiome.
  • Psychopathology of morbid obesity.
  • Genetic susceptibility as a predictor of weight loss.
  • Creation of a bank of adipose tissue samples for studies of aspects related to metabolism and hormonal secretion with intolerance to carbohydrates and / or energy balance.
  • Prader Willi and growth hormone.
  • Prader Willi. Study of hyperphagia. Gastrointestinal appetite and satiety peptides. Brain connectivity study.

Composition of the group

  • Assumpt Caixàs Pedragós (Group leader)
  • Tura Benítez Comas
  • Laura Blanco Fennel
  • Marta Bueno Ten
  • Laia Casamitjana Espuña
  • Ramon Coronas Borri
  • Yolanda Couto Rosende
  • Joan Deus Yela
  • Susanna Esteba Castillo
  • Olga Giménez Palop
  • Antonia Humanes Zamora
  • Marta Hurtado Ortuño
  • Laférrère Blandine
  • Albert Lecube Torelló
  • Marina Luengo Moral
  • Alexis Luna Aufroy
  • Gerard Martínez Vilavella
  • Sandra Montmany Vioque
  • Ramon Novell Alsina
  • Dew Franganillo Couple
  • Jesús Pujol Nuez
  • Pere Rebasa Cladera
  • Raquel Tirado Godàs
  • Roser Trallero Casañas

Group A4G2 - Diabetes - Cardiovascular risk

Accreditation level: Group in the consolidation phase

With more than 10 years of experience, the diabetes-cardiovascular risk group is multidisciplinary, incorporates specialists from other hospitals and its leader is part of CIBERDEM.

Areas of research

  • Improvement in the prediction of coronary events in patients with type 1 diabetes: The Group has developed a mathematical model with a high ability to predict the presence of silent myocardial ischemia in these patients. This model will be validated and enhanced with the addiction of new markers in the next 4 years.

Composition of the group

  • José Miguel González Clemente (Group leader)
  • Eugenio Berlanga Escalera
  • Albert Cano Palomares
  • Montserrat González Saltres
  • Gemma Plowed Cabot
  • Isabel Mazarico Altisent
  • Jordi Puntí Sala
  • Ato Antonio Rodríguez Revuelto

Group A4G3 - Diabetes

Accreditation level: Group in the consolidation phase

Areas of research

  • To study the factors that best predict the development of coronary events in patients with type 1 diabetes mellitus: The factors analyzed so far have been: classical cardiovascular risk factors, arterial stiffness, low grade inflammation, endothelial dysfunction, advanced glycosylation, diabetic retinopathy, haptoglobin genotype and mineral metabolism. It is expected to study in the next 4 years: DNA methylations, homocysteineemia, microRNAs, glycemic variability, D-peptic acid, glucagon, GLP-1, lipoproteins and retinal neurodegeneration.

Composition of the group

  • Mercedes Rigla Cros (Group leader)
  • Monserrat Aguilar Gázquez
  • Lara Albert Fàbregas
  • Ismael Capel Flores
  • Maria Gallach Figueras
  • Ana Méndez López
  • Belén Pons Pons
  • David Subías Andújar

Group A4G4 - Inflammatory bowel, liver and helicobacter pilori disease

Accreditation level: Consolidated group

Composition of the group

  • Xavier Calvet Calvo (Group leader)
  • Enric Brullet Benedi
  • Rafel Campo Fernández de los Ríos
  • Meritxell Casas Rodrigo
  • Blai Dalmau Obrador
  • Angelina Dosal Galguera
  • Ariadna Figuerola Ferrer
  • Marta Gallach Montero
  • Pilar García Iglesias
  • Félix Junquera Flórez
  • Sergio Lario García
  • Eva Martínez Bauer
  • Mireia Miquel Planas
  • Teresa Monllor Nunell
  • Antònia Montserrat Torres
  • Valentí Puig Diví
  • M. José Ramírez Lázaro
  • Sílvia Rodríguez Cerrillo
  • Jordi Sánchez Delgado
  • Mercè Vergara Gómez
  • Albert Villoria Ferrer

Group A4G5 - Inflammatory joint disease, bone metabolism and systemic autoimmune diseases

Accreditation level: Consolidated group

Areas of research

  • Systemic autoimmune rheumatic diseases
  • Spondyloarthritis
  • Inflammation and articular cartilage:
  • Inflammation and bone metabolism
  • Inflammation and skin (hydrosadenitis and psoriasis)
  • Systemic autoimmune diseases (MDI)

Composition of the group

  • Jordi Gratacós Masmitjà (Group leader)
  • Marta Arévalo Salaert
  • Rafael Azagra Ledesma
  • Joan Calvet Fontova
  • Enrique Married Burgos
  • Elsa Dalmau Pórtulas
  • Luis Miguel Del Río Barquero
  • Juan Francisco Thin of the Poza
  • Carlos Galistero Lecantre de Vega
  • María García Manríquez
  • Antonio Gómez Centeno
  • Eduard Graell Martín
  • Marta Larrosa Padró
  • Jesús Luelmo Aguilar
  • Begoña Marí Alfonso
  • Manuel Monteagudo Jiménez
  • Marta Moreno Iturriaga
  • Mireia Moreno Martínez-Losa
  • María Luisa Morera Morales
  • Noemí Navarro Rich
  • Cristobal Orellana Garrido
  • Joaquim Oristrell Salvà
  • Daniel Prieto Alhambra
  • Miquel Ribera Pibernat
  • Jorge Rosemary of Gabriel
  • Carles Tolosa Vilella
  • Ferran Torres

Group A4G7 - Translational research in the critical patient

Accreditation level: Consolidated group

The studies attached to this line are developed within the CIBER of Respiratory Diseases (CIBERES), of which we have been part of since 2008 and of the Consolidated Research Group recognized in 2014 by the AGAUR (SGR955). The team participates in several scientific societies related to the critically ill patient (SOCMIC and SEMICYUC) and international (ESICM, ERS, ATS).

Our lines are oriented to translational research in the field of pathophysiology associated with the critical patient and are focused on the study of respiratory and cardiovascular pathophysiology, sepsis and its management in the ICU. Our challenge over the next few years is to approach the study of critical patient-associated pathology from a broad, comprehensive, multidisciplinary, humanized and patient-centered perspective and to foster strategies that allow us to tailor treatments to our particular needs. and at the follow-up of these patients beyond discharge from the ICU (post-ICU syndrome).

The research team is multidisciplinary and is composed of researchers of different profiles, which allows the development of clinical and preclinical research projects. In parallel, and thanks to the incorporation of engineers, we work in a cross-cutting way with new technological developments applied to monitoring and therapeutic innovation.

The preclinical research is complemented and carried out in parallel with the clinical studies carried out in ICU patients, favoring the translational perspective. We work on the development of experimental models that recreate pathologies associated with the critically ill (SDRA, LPA, sepsis), both in vivo (animal models) and in vitro (cell cultures).

Areas of research

  • Respiratory pathophysiology in the critical patient.
  • Cardiovascular dysfunction, hemodynamic monitoring and sepsis in the critical patient.
  • Humanization.
  • Collection and processing of biomedical signals.
  • Experimental models and associated treatments.

Composition of the group

  • Josefina López Aguilar (Group leader)
  • Antoni Artigas Raventós
  • Lluís Blanch Torra
  • Josep Brinqué Roqué
  • Marta Camprubí Jordán
  • Haro López candlestick
  • Cristina Espinal Sacristan
  • Sun Fernandez Gonzalo
  • Gemma Gomà Fernández
  • Víctor Gómez Simón
  • Guillem Gruartmoner de Vera
  • Manel Lujan I came back
  • Rudys Magrans Nicieza
  • Jaume Mesquida February
  • Jaume Montanyà Castells
  • Guillermo Muñiz Albaiceta
  • Ana Navas Pérez
  • Ana Ochagavia Calvo
  • Cristina Pérez Madrigal
  • Natalia Ridao Sais
  • Andrey Luis Rodriguez Yakushev
  • Eva Torrents Lara
  • Marc Turon Viñas

Group A4G9 - Airway inflammation and sleep disorders

Accreditation level: Consolidated group

Areas of research

  • COPD.
  • Inflammation and repair in lung cancer.
  • Interstitial respiratory diseases.
  • Inflammatory response in respiratory infection.
  • Microbiome in chronic respiratory diseases.
  • Rehabilitation in respiratory chronicity.
  • Sleep disturbance.
  • Asthma.

Composition of the group

  • Eduard Monsó Molas (Group leader)
  • María Isabel Arranz Cardaba
  • Alda Cardesin Revilla
  • Roser Coll Fernández
  • Christian Domingo Ribas
  • Júlia Estela Esteve
  • Ana Galera Winter
  • Carles Grimau Chapinal
  • Cristina Lalmolda Puyol
  • Helena Larramona Carrera
  • Natalia Martínez López
  • M. José Masdeu Margalef
  • Georgina Mateu Vives
  • Laura Millares Costa
  • Daniel-Ross Monserrate Mitchell
  • Conception Montón Soler
  • Amàlia Moreno Gómez de Bonilla
  • Mariona Noray Malgrat
  • Look at Josune Ormaza Landabaso
  • Maria Piñar Fernández
  • Xavier Pomares Amigó
  • Enriqueta Ramírez Prat
  • Rosa Rosell Ferrer
  • Laura Samarà Piñol
  • Laia Setó Gorg
  • Ana Sogo Sagardia
  • Laura Vigil Giménez